Randomized Phase III Study Comparing Paclitaxel–Bleomycin, Etoposide, and Cisplatin (BEP) to Standard BEP in Intermediate-Prognosis Germ-Cell Cancer: Intergroup Study EORTC 30983
نویسندگان
چکیده
منابع مشابه
Is CBOP/BEP an alternative to BEP for patients with poor prognosis metastatic germ cell tumours?
Correspondence to A Addeo; alfredo.addeo@ uhbristol.nhs.uk The management of metastatic germ cell tumours (GCTs) with platinum-based chemotherapy represents a major success story. However, patients with poor-prognosis nonseminomatous GCTs (NSGCTs) with high tumour markers, non-pulmonary visceral metastases, or a mediastinal primary site at presentation have a less certain outcome. This group ac...
متن کاملA randomized phase III study comparing standard dose BEP with sequential high-dose cisplatin, etoposide, and ifosfamide (VIP) plus stem-cell support in males with poor-prognosis germ-cell cancer. An intergroup study of EORTC, GTCSG, and Grupo Germinal (EORTC 30974).
BACKGROUND To compare the efficacy of one cycle of standard dose cisplatin, etoposide, and ifosfamide (VIP) plus three cycles of high-dose VIP followed by stem-cell infusion [high-dose chemotherapy (HD-CT arm)] to four cycles of standard cisplatin, etoposide, and bleomycin (BEP) in patients with poor-prognosis germ-cell cancer (GCC). PATIENT AND METHODS Patients with poor-prognosis GCC were a...
متن کاملRandomized phase III study comparing paclitaxel/cisplatin/gemcitabine and gemcitabine/cisplatin in patients with locally advanced or metastatic urothelial cancer without prior systemic therapy: EORTC Intergroup Study
carcinoma. Urol Clin North Am 2010; 37: 467–474. 136. Hussein AM, Benedetto P, Sridhar KS. Chemotherapy with cisplatin and 5fluorouracil for penile and urethral squamous cell carcinomas. Cancer 1990; 65: 433–438. 137. Shammas FV, Ous S, Fossa SD. Cisplatin and 5-fluorouracil in advanced cancer of the penis. J Urol 1992; 147: 630–632. 138. Di Lorenzo G, Buonerba C, Federico P et al. Cisplatin an...
متن کاملA Phase III Randomized Study Comparing a Chemotherapy with Cisplatin and Etoposide to a Etoposide Regimen without Cisplatin for Patients with Extensive Small-Cell Lung Cancer
INTRODUCTION In a literature meta-analysis, we showed survival benefits for regimens including cisplatin [hazard ratio (HR) 0.61; 95% confidence interval (CI), 0.57-0.66] and for those including etoposide (HR 0.65; 0.61-0.69). That benefit was mainly observed when etoposide alone or in combination with cisplatin was included in the chemotherapy regimens. Our objective was to determine if chemot...
متن کاملIntensive induction chemotherapy with CBOP/BEP in patients with poor prognosis germ cell tumors.
PURPOSE Despite a high cure rate in patients with testicular cancer, there remain patients in the poor prognosis group who have a less favorable outcome. Intensive induction chemotherapy using a regimen consisting of carboplatin, bleomycin, vincristine, and cisplatin, followed by bleomycin, etoposide, and cisplatin (CBOP/BEP), developed at the Royal Marsden Hospital, is designed to overcome the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Oncology
سال: 2012
ISSN: 0732-183X,1527-7755
DOI: 10.1200/jco.2011.37.0171